Adipogenesia, osasunaren etsai edo lagun?
نویسندگان
چکیده
Gantz-ehun zuria (GEZ) gorputzeko energia-biltegia da eta adipozito izena duten zelulez osaturik dago. Giza gorputzean duen kokalekuaren arabera, larruazalpeko GEZ (LGEZ) erraietako (EGEZ) bereizten dira. Adipozitoei dagokienez, EGEZko adipozitoak LGEZkoak baino aktiboagoak dira metabolikoki; azken horiek, berriz, tamaina handiagoa lipidoak hartzeko gaitasun dute. Obesitateak GEZren hazkunde edo hedapena eragiten du, bi modutan: adipozitoen kopurua handituz (hiperplasia hipertrofia, hurrenez hurren). GEZn gertatzen diren aldaketa ehun honen funtzionamendu egokian eragin dezakete. Horrela, hipertrofia bidez den obesitatearekin hari lotutako gaixotasun metabolikoekin erlazio- natzen da. Adipozitoen hipertrofiak hiperplasiak komorbilitateetan garrantziaz jabetzeko, «metabolikoki osasuntsuak obesoak» «argal faltsuak» terminoak aipatu behar Lehenengoen kasuan, obesitateaz gain ez gainerako asaldura metabolikorik izango. Bigarrengoen pisu egokia izan arren zitokina hantura-eragileen maila handiagoak izaten dituzte odolean. Etorkizunari begira, argi geratzen pertsona obesoen gantz-gordailuen ezaugarritu zein identifikatzea ahalbidetuko ikerketa gehiagoren beharra.
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ژورنال
عنوان ژورنال: Ekaia
سال: 2021
ISSN: ['0214-9001', '2444-3255']
DOI: https://doi.org/10.1387/ekaia.21682